Mikk Tooming MSc student Jekaterina Krasohhina
BSc student
Our resarch interests:
* Regenerative biology - the role of
progenitor cells in liver regeneration
* Extracellular matrix - the role of ECM in modulating the activity of stem and
differentiated cells during organ regeneration.
* Stem cell niche - the composition and fucntions of immediate microenvirinment surrounding stem/progenitro cells.
* Tissue engineering - generation of
miniature artificial organs for research and applied purposes
* Immunology - the role of immune cells in tissue regeneration
Publications:
Viil, Janeli; Klaas,
Mariliis; Valter, Kadri; Beliš̌kin, Denis; Ilmjärv, Sten; Jaks, Viljar
(2017). A label-retaining but unipotent cell population resides in
biliary compartment of mammalian liver. Scientific Reports, 7, Article
number: 40322
Mäemets-Allas,
Kristina; Belitškin, Denis; Jaks, Viljar (2016). The inhibition of
Akt-Pdpk1 interaction efficiently suppresses the growth of murine
primary liver tumor cells. Biochemical and Biophysical Research
Communications, 474 (1), 118−125
Klaas, Mariliis;
Kangur, Triin; Viil, Janeli; Mäemets-Allas, Kristina; Minajeva, Ave;
Vadi, Krista; Antsov, Mikk; Lapidus, Natalia; Järvekülg, Martin; Jaks,
Viljar (2016). The alterations in the extracellular matrix composition
guide the repair of damaged liver tissue. Scientific Reports, 6,
Article number: 27398
Urgard, Egon; Lorents,
Annely; Klaas, Mariliis; Padari, Kärt; Viil, Janeli; Runnel, Toomas;
Langel, Kent; Kingo, Kü̈lli; Tkaczyk, Eric; Langel, Ülo; Maimets,
Toivo; Jaks, Viljar; Pooga, Margus; Rebane, Ana (2016).
Pre-administration of PepFect6-microRNA-146a nanocomplexes inhibits
inflammatory responses in keratinocytes and in a mouse model of
irritant contact dermatitis. Journal of Controlled Release, 235,
195−2014
Kasper, Maria; Toftgård, Rune; Jaks, Viljar (2016). Isolation and
Fluorescence-Activated Cell Sorting of Mouse Keratinocytes Expressing
β-Galactosidase. Methods in molecular biology (Clifton, N.J.), 1453,
123−136
Mäemets-Allas, K.; Viil, J.; Jaks, V. (2015). A novel inhibitor of
AKT1-PDPK1 interaction efficiently suppresses the activity of AKT
pathway and restricts tumor growth in vivo. Molecular cancer
therapeutics, 28, 17, 144
Pook, Martin; Teino, Indrek; Kallas, Ade; Maimets, Toivo; Ingerpuu,
Sulev; Jaks, Viljar (2015). Changes in laminin expression pattern
during early differentiation of human embryonic stem cells. PLoS ONE,
10 (9), e0138346
Viil, J.; Maasalu, K.; Mäemets-Allas, K4., Tamming, Lõhmussaar, K.;
Tooming, M.; Ingerpuu, S.; Märtson, A.; Jaks, V. (2015). Laminin-rich
blood vessels display activated growth factor signaling and act as the
proliferation centers in Dupuytren's contracture. Arthritis Research
and Therapy, 17 (1), Article number 144
Reemann, P.; Reimann, E.; Ilmjärv, S.; Porosaar, O.; Silm, H.; Jaks,
V.; Vasar, E.; Kingo, K.; Kõks, S. (2014). Melanocytes in the skin -
comparative whole transcriptome analysis of main skin cell types. PLoS
ONE, 9 (12), e115717
Siimon, Kaido; Reemann, Paula; Põder, Annika; Pook, Martin; Kangur,
Triin; Kingo, Külli; Jaks, Viljar; Mäeorg, Uno; Järvekülg, Martin
(2014). Effect of glucose content on thermally cross-linked fibrous
gelatin scaffolds for tissue engineering. Materials Science and
Engineering C, 538−545
Pook, M.; Tamming, L.; Padari, K.; Tiido, T.; Maimets, T.; Patarroyo,
M.; Juronen, E.; Jaks, V.; Ingerpuu, S. (2014). Platelets store
laminins 411/421 and 511/521 in compartments distinct from α- or dense
granules and secrete these proteins via microvesicles. Journal of
Thrombosis and Haemostasis, 12 (4), 519−527
Chari, N.S.; Romano, R.A.; Koster, M.I.; Jaks, V.; Roop, D.; Flores,
E.R.; Teglund, S.; Sinha, S.; Gruber, W.; Aberger, F.; Medeiros, L.J.;
Toftgard, R.; McDonnell, T.J. (2013). Interaction between the TP63 and
SHH pathways is an important determinant of epidermal homeostasis. Cell
Death and Differentiation, 20 (8), 1080−1088
van Dop, W.A; Rosekrans, S.L.; Uhmann, A.; Jaks, V.; Offerhaus, G.J.;
van den Bergh Weerman, M.A.; Kasper, M; Heijmans, J.; Hardwick, J.C.;
Verspaget, H.W.; Hommes, D.W.; Toftgård, R.; Hahn, H.; van den Brink,
G.R. (2013). Hedgehog signalling stimulates precursor cell accumulation
and impairs epithelial maturation in the murine oesophagus. GUT, 62
(3), 348−357
Reemann, Paula; Kangur, Triin; Pook, Martin; Paalo, Madis; Nurmis,
Liis; Kink, Ilmar; Porosaar, Orm; Kingo, Kü̈lli; Vasar, Eero; Kõks,
Sulev; Jaks, Viljar; Järvekülg, Martin (2013). Fibroblast growth on
micro- and nanopatterned surfaces prepared by a novel sol-gel phase
separation method. Journal of Materials Science: Materials in Medicine,
24 (3), 783−792,
Kasper, M.*; Jaks, V.*;
Hohl, D.; Toftgård, R. (2012). Basal cell carcinoma - molecular
biology and potential new therapies. Journal of Clinical Investigation,
122 (2), 455−263
Kasper, Maria*; Jaksa, Viljar*; Are, Alexandra; Bergström, Åsa ;
Schwäger, Anja; Barker, Nick; Toftgård, Rune. (2011). Wounding
enhances epidermal tumorigenesis by recruiting hair follicle
keratinocytes. Proceedings of the National Academy of Sciences of the
United States of America, 108 (10), 4099−4104
Jaks, V.; Kasper, M.
and Toftgård, R. (2010). The hair follicle-a stem cell zoo.
Experimental Cell Research, 1422−1428
Snippert, H.J.;
Haegebarth, A.; Kasper, M.; Jaks, V.; van Es, J.H.; Barker N, van de
Wetering, M.; van den Born, M.; Begthel, H.; Vries, R.G.; Stang, D.E.;
Toftgård, R. and Clevers, H. (2010). Lgr6 stem cells generate all cell
lineages of the skin. Science, 327, 1385−1389
Kasper M*, Jaks V*,
Fiaschi M, Toftgård R. (2009). Hedgehog signalling in breast cancer.
Carcinogenesis, 30 (6), 903−911
Jaks, Viljar; Barker,
Nick; Kasper, Maria; van Es, Johan H; Snippert, Hugo J.; Clevers, Hans;
Toftgård, Rune (2008). Lgr5 marks cycling, yet long-lived, hair
follicle stem cells. Nature Genetics, 40 (11), 1291−1299
Barker, N; van Es, JH;
Jaks, V; Kasper, M; Snippert, H; Toftgård, R; Clevers, H. (2008). Very
Long-term Self-renewal of Small Intestine, Colon, and Hair Follicles
from Cycling Lgr5+ve Stem Cells. Cold Spring Harbor Symposia on
Quantitative Biology, 73. Cold Spring Harbor Laboratories Press, 351−356
Pauklin, S.;
Kristjuhan, A.; Maimets, T.; Jaks, V. (2005). ARF and ATM/ATR cooperate
in p53-mediated apoptosis upon oncogenic stress. Biochemical and
Biophysical Research Communications, 334 (2), 386−394