Tissue regeneration group

University of TartuInstitute of Molecular and Cell Biology


Viljar Jaks Mariliis Klaas Kristina Mäemets-Allas
Viljar Jaks, MD, PhD
Senior reserach fellow
Contact: Riia 23b-220
 Phone +372 737 4096 viljar.jaks@ut.ee
Mariliis Klaas, PhD
Kristina Mäemets-Allas, PhD

Mikk Tooming MSc student
Jekaterina Krasohhina BSc student

Our resarch interests:

* Regenerative biology - the role of progenitor cells in liver regeneration

* Extracellular matrix - the role of ECM in modulating the activity of stem and differentiated cells during organ regeneration.

* Stem cell niche - the composition and fucntions of immediate microenvirinment surrounding stem/progenitro cells.

* Tissue engineering - generation of miniature artificial organs for research and applied purposes

* Immunology - the role of immune cells in tissue regeneration


Viil, Janeli; Klaas, Mariliis; Valter, Kadri; Beliš̌kin, Denis; Ilmjärv, Sten; Jaks, Viljar (2017). A label-retaining but unipotent cell population resides in biliary compartment of mammalian liver. Scientific Reports, 7, Article number: 40322

Mäemets-Allas, Kristina; Belitškin, Denis; Jaks, Viljar (2016). The inhibition of Akt-Pdpk1 interaction efficiently suppresses the growth of murine primary liver tumor cells. Biochemical and Biophysical Research Communications, 474 (1), 118−125

Klaas, Mariliis; Kangur, Triin; Viil, Janeli; Mäemets-Allas, Kristina; Minajeva, Ave; Vadi, Krista; Antsov, Mikk; Lapidus, Natalia; Järvekülg, Martin; Jaks, Viljar (2016). The alterations in the extracellular matrix composition guide the repair of damaged liver tissue. Scientific Reports, 6, Article number: 27398

Urgard, Egon; Lorents, Annely; Klaas, Mariliis; Padari, Kärt; Viil, Janeli; Runnel, Toomas; Langel, Kent; Kingo, Kü̈lli; Tkaczyk, Eric; Langel, Ülo; Maimets, Toivo; Jaks, Viljar; Pooga, Margus; Rebane, Ana (2016). Pre-administration of PepFect6-microRNA-146a nanocomplexes inhibits inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis. Journal of Controlled Release, 235, 195−2014

Kasper, Maria; Toftgård, Rune; Jaks, Viljar (2016). Isolation and Fluorescence-Activated Cell Sorting of Mouse Keratinocytes Expressing β-Galactosidase. Methods in molecular biology (Clifton, N.J.), 1453, 123−136

Mäemets-Allas, K.; Viil, J.; Jaks, V. (2015). A novel inhibitor of AKT1-PDPK1 interaction efficiently suppresses the activity of AKT pathway and restricts tumor growth in vivo. Molecular cancer therapeutics, 28, 17, 144

Pook, Martin; Teino, Indrek; Kallas, Ade; Maimets, Toivo; Ingerpuu, Sulev; Jaks, Viljar (2015). Changes in laminin expression pattern during early differentiation of human embryonic stem cells. PLoS ONE, 10 (9), e0138346

Viil, J.; Maasalu, K.; Mäemets-Allas, K4., Tamming, Lõhmussaar, K.; Tooming, M.; Ingerpuu, S.; Märtson, A.; Jaks, V. (2015). Laminin-rich blood vessels display activated growth factor signaling and act as the proliferation centers in Dupuytren's contracture. Arthritis Research and Therapy, 17 (1), Article number 144

Reemann, P.; Reimann, E.; Ilmjärv, S.; Porosaar, O.; Silm, H.; Jaks, V.; Vasar, E.; Kingo, K.; Kõks, S. (2014). Melanocytes in the skin - comparative whole transcriptome analysis of main skin cell types. PLoS ONE, 9 (12), e115717

Siimon, Kaido; Reemann, Paula; Põder, Annika; Pook, Martin; Kangur, Triin; Kingo, Külli; Jaks, Viljar; Mäeorg, Uno; Järvekülg, Martin (2014). Effect of glucose content on thermally cross-linked fibrous gelatin scaffolds for tissue engineering. Materials Science and Engineering C, 538−545

Pook, M.; Tamming, L.; Padari, K.; Tiido, T.; Maimets, T.; Patarroyo, M.; Juronen, E.; Jaks, V.; Ingerpuu, S. (2014). Platelets store laminins 411/421 and 511/521 in compartments distinct from α- or dense granules and secrete these proteins via microvesicles. Journal of Thrombosis and Haemostasis, 12 (4), 519−527

Chari, N.S.; Romano, R.A.; Koster, M.I.; Jaks, V.; Roop, D.; Flores, E.R.; Teglund, S.; Sinha, S.; Gruber, W.; Aberger, F.; Medeiros, L.J.; Toftgard, R.; McDonnell, T.J. (2013). Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis. Cell Death and Differentiation, 20 (8), 1080−1088

van Dop, W.A; Rosekrans, S.L.; Uhmann, A.; Jaks, V.; Offerhaus, G.J.; van den Bergh Weerman, M.A.; Kasper, M; Heijmans, J.; Hardwick, J.C.; Verspaget, H.W.; Hommes, D.W.; Toftgård, R.; Hahn, H.; van den Brink, G.R. (2013). Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus. GUT, 62 (3), 348−357

Reemann, Paula; Kangur, Triin; Pook, Martin; Paalo, Madis; Nurmis, Liis; Kink, Ilmar; Porosaar, Orm; Kingo, Kü̈lli; Vasar, Eero; Kõks, Sulev; Jaks, Viljar; Järvekülg, Martin (2013). Fibroblast growth on micro- and nanopatterned surfaces prepared by a novel sol-gel phase separation method. Journal of Materials Science: Materials in Medicine, 24 (3), 783−792,

Kasper, M.*; Jaks, V.*; Hohl, D.; Toftgård, R. (2012). Basal cell carcinoma - molecular biology and potential new therapies. Journal of Clinical Investigation, 122 (2), 455−263

Kasper, Maria*; Jaksa, Viljar*; Are, Alexandra; Bergström, Åsa ; Schwäger, Anja; Barker, Nick; Toftgård, Rune. (2011). Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proceedings of the National Academy of Sciences of the United States of America, 108 (10), 4099−4104

Jaks, V.; Kasper, M. and Toftgård, R. (2010). The hair follicle-a stem cell zoo. Experimental Cell Research, 1422−1428

Snippert, H.J.; Haegebarth, A.; Kasper, M.; Jaks, V.; van Es, J.H.; Barker N, van de Wetering, M.; van den Born, M.; Begthel, H.; Vries, R.G.; Stang, D.E.; Toftgård, R. and Clevers, H. (2010). Lgr6 stem cells generate all cell lineages of the skin. Science, 327, 1385−1389

Kasper M*, Jaks V*, Fiaschi M, Toftgård R. (2009). Hedgehog signalling in breast cancer. Carcinogenesis, 30 (6), 903−911

Jaks, Viljar; Barker, Nick; Kasper, Maria; van Es, Johan H; Snippert, Hugo J.; Clevers, Hans; Toftgård, Rune (2008). Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nature Genetics, 40 (11), 1291−1299

Barker, N; van Es, JH; Jaks, V; Kasper, M; Snippert, H; Toftgård, R; Clevers, H. (2008). Very Long-term Self-renewal of Small Intestine, Colon, and Hair Follicles from Cycling Lgr5+ve Stem Cells. Cold Spring Harbor Symposia on Quantitative Biology, 73. Cold Spring Harbor Laboratories Press, 351−356

Pauklin, S.; Kristjuhan, A.; Maimets, T.; Jaks, V. (2005). ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress. Biochemical and Biophysical Research Communications, 334 (2), 386−394